Treatment of second recurrence of CDI

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Review severity markers (see Severity of Infection) and contact infection specialist for advice (see How to get advice).

Faecal microbiota transplant (FMT) is recommended and requires referral to infectious diseases - bleep 8161.

If FMT not available considering tapering oral vancomycin regime as below:

Tapering vancomycin course

Week 1 - Vancomycin 125mg every 6 hours

Week 2 - Vancomycin 125mg every 12 hours

Week 3 - Vancomycin 125mg daily

Week 4 - Vancomycin 125mg alternate days

Week 5 - Vancomycin 125mg every third day

If further recurrences specialist advice is required (see How to get advice).