Acute Infective Exacerbation of COPD

Treat exacerbations promptly with antibiotics if purulent sputum and increased shortness of breath and/or increased sputum volume.

Note: Use of an antibiotic is not recommended in the absence of purulent sputum.

Risk factors for antibiotic resistant organisms include co-morbid disease, severe COPD, frequent exacerbations, antibiotics in last 3 months.

Link to patient information leaflet


500mg three times daily

5 days

or Erythromycin

500mg four times daily

5 days

or Doxycycline

200mg stat then 100mg once daily

5 days

If resistance: co-amoxiclav

625mg three times daily

5 Days