Clostridioides difficile (Clostridium Difficile)


Stop unnecessary antibiotics and/or PPIs to re-establish normal flora.

Review and stop anti-motility agents and laxatives.

Admit if severe:

T >38.5oC, or WCC >15, or rising creatinine (>1.5 x baseline) or signs/symptoms of severe colitis.

No test of cure required

1st episode and NO severity markers:




400mg 3 x daily

child dose



10 days

2nd episode or no improvement after 5 days metronidazole:

oral Vancomycin



 125mg 4 x daily

child dose



10 days