Clostridioides difficile (Clostridium Difficile)

HPS 

Stop unnecessary antibiotics and/or PPIs to re-establish normal flora.

Review and stop anti-motility agents and laxatives.

Admit if severe:

T >38.5oC, or WCC >15, or rising creatinine (>1.5 x baseline) or signs/symptoms of severe colitis.

No test of cure required

1st episode and NO severity markers:

Metronidazole

 

 

400mg 3 x daily

child dose

 

 

10 days

2nd episode or no improvement after 5 days metronidazole:

oral Vancomycin

 

 

 125mg 4 x daily

child dose

 

 

10 days