Drug Dosing
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Antibiotic Prophylaxis in Surgery - Drug Dosing
ANTIBIOTIC | DOSE | ADMINISTRATION | PROLONGED SURGERY - RECOMMENDED REDOSING | >1.5L BLOOD LOSS - REDOSE AFTER FLUID REPLACEMENT |
Amoxicillin | 1g IV | Bolus over 3-4 minutes | 500mg after 4 hours | 500mg |
Cefuroxime | 1.5g IV | Bolus over 3-4 minutes | 750mg after 4 hours | 750mg |
Ciprofloxacin | 1000mg PO | 1 hour pre-procedure | N/A | N/A |
Co-amoxiclav | 1.2g IV | Bolus over 3-4 minutes | 600mg after 4 hours | 600mg |
Clindamycin | 600mg IV | Infuse over 10-60 minutes | 300mg after 4 hours | 300mg |
Flucloxacillin | 1g IV | Bolus over 3-4 minutes | 500mg after 4 hours | 500mg |
Gentamicin |
3mg/kg IV Use ideal body weight (IBW) if >20% overweight - see below
Do not repeat dose unless >1.5l blood loss |
Bolus over 2-3 minutes. Can also be given as short infusion |
If surgery >8 hours, re - dose at half pre-op dose if no renal impairment |
2mg/kg IBW |
Metronidazole | 500mg IV | Infuse over 20 minutes | 500mg after 8 hours | 500mg |
Teicoplanin |
<65kg 400mg 66-99kg 600mg 100-130kg 800mg 131-166kg 1000mg |
Infuse over 3-4 minutes | Re-dosing not required | Re-dosing not required |
*IBW= (males: 50kg /females 45.5kg)
+0.9kg for every cm>150cm