Cellulitis - Spreading or severe sepsis

First Line

Flucloxacillin IV + Amoxicillin IV + Clindamcyin IV for 7-14 days

Second line: mild intolerance or mild skin reaction

Ceftriaxone IV + Clindamycin IV for 7-14 days

Anaphylaxis to penicillin / cephalosporins (severe allergy) or MRSA

Vancomcyin IV + Clindamycin IV for 7-14 days

Notes

Discuss with microbiology for IV to oral switch