Infective Endocarditis - Native valve endocarditis

Micro Organisms

Strep. viridians, Staph. aureus

First Line

Therapy

Amoxicillin IV + gentamicin IV (treatment dose - not synergistic dose)+/- flucloxacillin IV for 4-6 weeks

Discuss with specialist for course length of gentamicin

Penicillin Allergy or MRSA suspected or confirmed

Therapy

Vancomycin IV + gentamicin IV (treatment dose - not synergistic dose) for 4 -6 weeks

Discuss with specialist re course length of gentamicin

 

Notes:

Target vancomycin level - Trough: 15-20mg/l for pulsed infusion.

Notes

Use paediatric gentamicin for dosing guidance and target levels