Sepsis - Unknown Origin

First Line

 Gentamicin IV as per protocol  AND Amoxicillin 1g IV 8 hrly AND Metronidazole 500mg IV 8 hrly 

(if staphylococcal infection suspected (eg IVDU) add  flucloxacillin 2g IV 6 hrly)

(Use co-amoxiclav 1.2g IV 8 hrly if concerns re nephrotoxicity)


Add vancomycin IV as per protocol if MRSA suspected/ confirmed

Penicillin Allergy

Vancomycin IV as per protocol AND Gentamicin IV as per protocol AND Metronidazole 500mg IV 8hrly


Send blood cultures  and other relevant samples

Check previous / recent microbiology results for guidance

Check previous MRSA status


If there is treatment failure/relapse check microbiology results, seek senior clinical review +/- D/W microbiology