Sepsis - Unknown Origin
Gentamicin IV as per protocol AND Amoxicillin 1g IV 8 hourly AND Metronidazole 500mg IV 8 hourly
(if Staphylococcal infection suspected (eg IVDU) ADD Flucloxacillin 2g IV 6 hourly)
If concerns regarding nephrotoxicity e.g. acute kidney injury - replace Gentamicin with Temocillin IV dosed per Renal Drug Database
Vancomycin IV as per protocol AND Gentamicin IV as per protocol AND Metronidazole 500mg IV 8 hourly
If concerns regarding nephrotoxicity e.g. acute kidney injury - replace Gentamicin with Aztreonam IV dosed per Renal Drug Database
Send blood cultures and other relevant samples
Check previous / recent microbiology results for guidance
Check previous MRSA status
Treatment duration: Guided by source of infection after investigation and clinical response. Refer to appropriate header in guidance.
If there is treatment failure/relapse check microbiology results, seek senior clinical review +/- discuss with Microbiology consultant.