Neutropenic Sepsis - Non Haematology / Oncology

First Line

Piperacillin4g/tazobactam 500mg IV 6hrly +/- Gentamicin IV as per protocol

  • Review daily with microbiology results and de-escalate if possible


Add Vancomycin IV as per protocol if MRSA known or suspected

Penicillin Allergy

 Vancomycin as per protocol AND Ciprofloxacin 400mg IV 12 hrly  AND Metronidazole 500mg IV 8hrly


Send blood cultures  and other relevant samples

Check previous / recent microbiology results for guidance

Check previous MRSA status


If there is treatment failure/relapse check microbiology results, seek senior clinical review +/- D/W microbiology