Pneumonia In Immunocompromised

First Line

Piperacillin 4g/ tazobactam 500mg IV 6hrly

Add Clarithromycin 500mg IV 12 hrly if community acquired pneumonia suspected


Penicillin Allergy

Ciprofloxacin 400mg IV 12hrly AND Vancomycin IV  as per protocol

(No Clarithromycin required as ciprofloxacin has  atypical cover)

If already on ciprofloxacin prophylaxis

Vancomycin IV AND Gentamicin IV as per protocol AND  Clarithromycin 500mg IV 12 hrly 


e.g Immunosupressant drugs

Ensure sputum and atypical pneumonia screen (if appropriate) sent ASAP

If there is treatment failure/relapse check microbiology results, seek senior clinical review +/- D/W microbiology