Exacerbation of Bronchiectasis

First Line

Co-amoxiclav 1.2g IV 8 hourly +/- Clarithromycin (if atypical pneumonia is suspected or confirmed) 500 mg PO 12 hourly

 

If known to have Pseudomonas colonisation:

Ciprofloxacin 750mg PO 12 hourly consider safety issues) +/- Gentamicin IV as per protocol

or as guided by previous sensitivities

Penicillin Allergy

Levofloxacin 500mg PO 12 hourly (consider safety issues)

 

If known to have Pseudomonas colonisation:

Ciprofloxacin 750mg PO 12 hourly (consider safety issues) +/- Gentamicin IV as per protocol

or as guided by previous sensitivities

Notes

Ensure sputum sample sent ASAP prior to antibiotics

If there is treatment failure/relapse, review previous microbiology results and discuss with respiratory medicine and consultant microbiologist.

Treat for 7-14 days guided by clinical response and respiratory physician advice