Protected Antibiotics - Permitted Indications

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These antibiotics should ONLY be used for the indications listed below.

ALL OTHER USE MUST BE ON ADVICE OF CONSULTANT MICROBIOLOGIST / INFECTIOUS DISEASE CONSULTANT

Ceftazidime

  • Febrile neutropenia (haematology and oncology patients only)
  • Exacerbations of bronchiectasis or cystic fibrosis (if Pseudomonas colonisation/infection and penicillin allergy)

Ceftriaxone

  • Only on advice of consultant clinician (except in meningitis) or Microbiology or ID consultant
  • Meningitis

Clindamycin

  • Group A Streptococcal sepsis/toxic shock
  • Suspected or confirmed necrotising fasciitis
  • Soft tissue infections in penicillin allergic patients only when benefits outweigh risk and no other option available

Levofloxacin

  • As indicated in guideline in patients with true penicillin allergy
  • Strong clinical suspicion of Legionella infection

Linezolid

  • Only on advice of Microbiology or ID consultant

Meropenem - This may only be prescribed after consultation with senior member of clinical team

  • Exacerbation of bronchiectasis/cystic fibrosis if colonisation/infection with resistant Gram negative organisms including Pseudomonas
  • Febrile neutropenia (haematology/oncology patients)
  • Infections with multi resistant Gram negative bacilli as indicated by sensitivity report on culture
  • Severe sepsis unresponsive to Piperacillin/Tazobactam and Gentamicin

Teicoplanin

  • Vancomycin intolerance
  • Surgical prophylaxis (following guideline)
  • Out-patient and/or home parenteral antibiotic therapy (e.g. OPAT)

Temocillin

  • As indicated in the guidelines or after discussion with Microbiology consultant

Tigecycline

  • Only on advice of Microbiology or ID consultant