Pyrexia in Labour / Maternal Sepsis

First Line

Co-amoxiclav 1.2g IV 8 hourly  +/- Gentamicin IV as per protocol

 

Escalation

Piperacillin-Tazobactam (Tazocin) 4.5g IV 8 hourly  +/- Gentamicin IV as per protocol

Review daily with microbiology results and de-escalate if possible

Penicillin Allergy

Ceftriaxone 2g IV daily AND Metronidazole 500mg IV 8 hourly +/- Gentamicin IV as per protocol

 

If anaphylaxis to penicillin

Vancomycin IV as per protocol AND Gentamicin IV as per protocol AND Metronidazole 500mg IV 8 hourly

Notes

Send blood cultures  and other relevant samples

Check previous / recent microbiology results for guidance

Check previous MRSA status

If there is treatment failure/relapse check microbiology results, seek senior clinical review +/- D/W microbiology

 

Treatment duration: 7 days (if concern or evidence of endometritis - 14 days)