PROM

First Line

Benzylpenicillin 3g IV then 1.5g IV 4 hourly until delivery

Switch to oral Erythromycin 500mg QDS for a 7 day course

Penicillin Allergy

Cefuroxime 1.5g IV stat then 750mg IV 8 hourly if not a severe penicillin allergy

Vancomycin IV as per protocol if anaphylaxis / angioedema / urticaria or resp distress

Switch to oral Erythromycin 500mg QDS for a 7 day course

Notes

From RCOG guidelines