Pharyngitis with severe systemic infection/sepsis/toxic shock

First Line

Therapy

Benzylpenicillin 1.2g IV 4 hourly AND Clindamycin 1.2g IV 6 hourly

Penicillin Allergy

Therapy

Vancomycin IV as per protocol AND Clindamycin 1.2g IV 6 hourly 

Notes

Consider addition of IVIG, especially if poor response to immediate antibiotic therapy.