High Dose Antibiotic Therapy

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Some infections require treatment with a higher-dose of antibiotic. This could be because certain pathogens require a higher concentration of antibiotic to exert maximal effect (e.g. Pseudomonas and Ciprofloxacin) or because of how much antibiotic reaches a certain site in the body e.g. β-lactams and CNS infection.  

When considering use of an antibiotic that has been reported as “Sensitive at High Dose” against a pathogen, please use the following table. Note that these doses are for normal renal and hepatic function. Please use appropriate resources e.g Renal Drug Database, BNF for dose adjustment in patients with altered renal and/or hepatic function or discuss with clinical pharmacist.


Antibiotic High dose therapy

 Amoxicillin IV

 Amoxicillin PO

 Aztreonam IV

 Co-amoxiclav IV

 Co-amoxiclav PO

 Cefuroxime IV  

 Cefuroxime PO

 Ceftazidime IV

 Ceftriaxone IV

 Ciprofloxacin IV

 Ciprofloxacin PO

 Co-trimoxazole IV / PO

 Levofloxacin IV / PO

 Piperacillin-Tazobactam (Tazocin) IV


 2g 4 hourly

 1g 8 hourly

 2g 6 hourly​

 1.2g 8 hourly PLUS 1g Amoxicillin IV 8 hourly 

 625mg 8 hourly PLUS Amoxicillin 500mg 8 hourly

 1.5g 8 hourly

 500mg 12 hourly

 2g 8 hourly

 2g 12 hourly or 4g daily

 400mg 8 hourly

 750mg 12 hourly

 1.44g 12 hourly

 500mg 12 hourly

 4.5g 6 hourly

 2g 8 hourly