High Dose Antibiotic Therapy

exp date isn't null, but text field is

Some infections require treatment with a higher-dose of antibiotic. This could be because certain pathogens require a higher concentration of antibiotic to exert maximal effect (e.g. Pseudomonas and Ciprofloxacin) or because of how much antibiotic reaches a certain site in the body e.g. β-lactams and CNS infection.  

When considering use of an antibiotic that has been reported as “Sensitive at High Dose” against a pathogen, please use the following table. Note that these doses are for normal renal and hepatic function. Please use appropriate resources e.g Renal Drug Database, BNF for dose adjustment in patients with altered renal and/or hepatic function or discuss with clinical pharmacist.

 

Antibiotic	High dose therapy
Amoxicillin IV  Amoxicillin PO  Aztreonam IV  Co-amoxiclav IV  Co-amoxiclav PO  Cefuroxime IV    Cefuroxime PO  Ceftazidime IV  Ceftriaxone IV  Ciprofloxacin IV  Ciprofloxacin PO  Co-trimoxazole IV / PO  Levofloxacin IV / PO  Piperacillin-Tazobactam (Tazocin) IV  Temocillin	2g 4 hourly  1g 8 hourly  2g 6 hourly​  1.2g 8 hourly PLUS 1g Amoxicillin IV 8 hourly   625mg 8 hourly PLUS Amoxicillin 500mg 8 hourly  1.5g 8 hourly  500mg 12 hourly  2g 8 hourly  2g 12 hourly or 4g daily  400mg 8 hourly  750mg 12 hourly  1.44g 12 hourly  500mg 12 hourly  4.5g 6 hourly  2g 8 hourly