High Dose Antibiotic Therapy

exp date isn't null, but text field is

Some infections require treatment with a higher-dose of antibiotic. This could be because certain pathogens require a higher concentration of antibiotic to exert maximal effect (e.g. Pseudomonas and Ciprofloxacin) or because of how much antibiotic reaches a certain site in the body e.g. β-lactams and CNS infection.  

When considering use of an antibiotic that has been reported as “Sensitive at High Dose” against a pathogen, please use the following table. Note that these doses are for normal renal and hepatic function. Please use appropriate resources e.g Renal Drug Database, BNF for dose adjustment in patients with altered renal and/or hepatic function or discuss with clinical pharmacist.

 

Antibiotic High dose therapy

 Amoxicillin IV


 Amoxicillin PO


 Aztreonam IV


 Co-amoxiclav IV


 Co-amoxiclav PO


 Cefuroxime IV  


 Cefuroxime PO


 Ceftazidime IV


 Ceftriaxone IV


 Ciprofloxacin IV


 Ciprofloxacin PO


 Co-trimoxazole IV / PO


 Fluconazole IV / PO


 Levofloxacin IV / PO


 Piperacillin-Tazobactam (Tazocin) IV


 Temocillin      - CrCl (ml/min)  > 60 

                          - CrCl (ml/min)  40-60

                          - CrCl (ml/min)  20-40

                          - CrCl (ml/min)  < 20

 2g 4 hourly


 1g 8 hourly


 2g 6 hourly​


 1.2g 8 hourly PLUS 1g Amoxicillin IV 8 hourly 


 625mg 8 hourly PLUS Amoxicillin 500mg 8 hourly


 1.5g 8 hourly


 500mg 12 hourly


 2g 8 hourly


 2g 12 hourly or 4g daily


 400mg 8 hourly


 750mg 12 hourly


 1.44g 12 hourly 


 800mg daily


 500mg 12 hourly


 4.5g 6 hourly


 2g 8 hourly

 2g 12 hourly

 2g stat then 1g 12 hourly

 2g stat then 1g 24 hourly