Septic Arthritis

First Line

IV Flucloxacillin 2g 6 hourly + / - IV Gentamicin

Allergy: or previous MRSA Positive IV : Vancomycin + IV Gentamicin

If at high risk of gram-negative sepsis (elderly frail, recurrent UTI,and recent abdominal surgery) Seek Microbiology advice within 48 hours


Tissue culture and blood culture very important

Seek specialist advice


Joint aspirate culture and blood culture very important. Antibiotics to be adjusted depending on results. Consider MRSA status.