Necrotising Fasciitis

First Line

Flucloxacillin IV 2g 6 hourly

+

Ciprofloxacin IV 400mg 12 hourly (IV for 1st dose, then review if appropriate to switch patient to oral).

+

Clindamycin IV 600mg to 1.2g 6 hourly

Penicillin Allergy

Vancomycin IV (dosing as per guideline. Use Vancomycin calculator)

+

Ciprofloxacin IV 400mg 12 hourly (IV for 1st dose, then review if appropriate to switch patient to oral).

+

Clindamycin IV 600mg to 1.2g 6 hourly

Notes

Discuss with Consultant Microbiologist.