Spontaneous Bacterial Peritonitis (SBP)

Duration

5-7 days

First Line

Important: Therapy

Ceftriaxone 2g IV 24 hourly

Or, in Immediate (type 1) beta-lactam sensitivity

Important: Therapy

Vancomycin IV (dosing as per guidelines. Use vancomycin calculator)

+

Ciprofloxacin oral 500mg 12 hourly (IV if enteral route unavailable).

Consult Microbiologist if patient has been receiving a quinolone as SBP prophylaxis.

Prophylaxis of Spontaneous Bacterial Peritonitis

Important: Therapy

First Line

Ciprofloxacin 500mg oral daily

Second Line

Co-Trimoxazole 960mg oral daily