Uncomplicated Lower UTI in Pregnancy

Micro-organism

If positive urine cultures are available, therapy choices should be based on the released sensitivities. 

Duration

7 days

1st or 2nd trimester

Trimethoprim is contraindicated in the 1st trimester of pregnancy.

Nitrofurantoin 50mg PO every 6 hours (avoid if eGFR < 45ml/min)

Or Cefalexin 500mg PO every 8 hours 

2nd or 3rd Trimester

Nitrofurantoin is contraindicated in the 3rd trimester of pregnancy

Cefalexin 500mg PO 8 hourly

Or Trimethoprim 200mg PO 12 hourly

Trimethoprim is unlicensed for this indication.