Single Agent Regimens

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This guidance only applies if there are no previous culture results indicating resistance to the proposed oral agent and no positive cultures are available for the current infective episode.

If the current agent is available in an oral formulation, a direct conversion is possible - with the exception of PO Vancomycin; it is not absorbed from the GI tract and the PO formulation is therefore only indicated for treatment of C. difficile infection.

In pregnant patients, ciprofloxacin and doxycycline are  contraindicated - discuss appropriate empirical choices with an infection specialist.

IV agent	PO regimen
Meropenem	Co-Amoxiclav 625 mg every 8 hours; if penicillin allergic: Ciprofloxacin 500mg every 12 hours
Piperacillin-tazobactam	Co-Amoxiclav 625mg every 8 hours
Vancomycin	Doxycycline 200mg on day 1 and 100mg once daily thereafter
Gentamicin	see “combination regimens”