Stop unnecessary antibiotics and/or PPIs.
70% respond to metronidazole (MTZ) in 5 days; 92% in 14 days.
If severe symptoms or signs (below) should treat with oral vancomycin, review progress closely and/or consider hospital referral.
Definition of severe: T >38.5oC, or WCC >15, or rising creatinine or signs/symptoms of severe colitis.
400mg or 500mg TDS
2nd episode/severe/type 027:
Recurrent disease see rationale: oral vancomycin
125mg QDS, consider taper